TIMM23 PAM:Cargo TIMM23 PAM:Precursor Cargo MPP Cleaves Presequence of Matrix Precursors As inferred from yeast, the alpha subunit of the mitochondrial processing peptidase (MPP) binds presequences of mitochondrial precursors and the beta subunit cleaves the presequence. After cleavage, proteins destined for the matrix are drawn into the matrix by ATP-dependent interaction with mtHSP70 (HSPA9, homolog of yeast SSC1) of the PAM complex. Authored: May, B, 2011-05-21 EC Number: 3.4.24 Edited: May, B, 2011-05-21 Pubmed18174896 Pubmed19453276 Reactome Database ID Release 431299478 Reactome, http://www.reactome.org ReactomeREACT_118803 Reviewed: D'Eustachio, P, 2011-11-01 Reviewed: Endo, T, 2012-02-12