Cargo of TIMM22 Cargo of TIMM22 TIMM22 Inserts Proteins into Inner Membrane As inferred from the yeast TIM22 complex, human TIMM22 inserts precursor proteins into the inner membrane of the mitochondrion. The precursors are hydrophobic and may be chaperoned to TIMM22 by small TIM proteins (TIMM10, TIMM12) of the intermembrane space. In yeast, experimentally verified substrates of the TIM22 complex include AAC (ADP/ATP translocase 1, ANT, SLC25A4 in human), PIC, TIM22 (TIMM22 in human), and TIM23 (TIMM23 in human). Many other inner membrane proteins are anticipated to be substrates ofthe TIMM22 complex. Authored: May, B, 2011-05-23 Edited: May, B, 2011-05-23 Pubmed18174896 Pubmed19453276 Reactome Database ID Release 431307803 Reactome, http://www.reactome.org ReactomeREACT_118820 Reviewed: D'Eustachio, P, 2011-11-01 Reviewed: Endo, T, 2012-02-12