ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9) ACE2 Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002). Authored: May, B, 2011-11-19 EC Number: 3.4.17 Edited: May, B, 2011-11-19 GENE ONTOLOGYGO:0002003 Pubmed10924499 Pubmed10969042 Pubmed11815627 Pubmed15283675 Reactome Database ID Release 432022378 Reactome, http://www.reactome.org ReactomeREACT_147733 Reviewed: Joseph, J, 2012-08-06