Secreted ACE Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-8) Authored: May, B, 2011-11-19 Edited: May, B, 2011-11-19 GENE ONTOLOGYGO:0002003 Pubmed10536878 Pubmed12540854 Pubmed1848554 Pubmed1851160 Pubmed2558510 Pubmed3017438 Pubmed6269175 Pubmed6270633 Reactome Database ID Release 432065355 Reactome, http://www.reactome.org ReactomeREACT_147705 Reviewed: Joseph, J, 2012-08-06 Secreted Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II Secreted angiotensin-converting enzyme (ACE) cleaves 2 amino acid residues from the C-terminus of angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Wei et al. 1991). This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999). ACE is secreted ("shed") from membranes of endothelial cells by cleavage in the C-terminal region that removes the membrane anchor.