ACE Hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-8) Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II Angiotensin-converting enzyme (ACE) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Ehlers and Kirsch 1988). ACE is found at the plasma membrane of endothelial cells. This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999). Authored: May, B, 2011-11-19 Edited: May, B, 2011-11-19 GENE ONTOLOGYGO:0002003 Pubmed10536878 Pubmed12540854 Pubmed1668266 Pubmed1848554 Pubmed1851160 Pubmed2558510 Pubmed2846041 Pubmed3017438 Pubmed6269175 Pubmed6270633 Reactome Database ID Release 432022405 Reactome, http://www.reactome.org ReactomeREACT_147747 Reviewed: Joseph, J, 2012-08-06