Synapsin Dopamine loaded synaptic vesicle Docked dopamine loaded synaptic vesicle Rab3-RIM complex Dopamine synaptic vesicle docking and priming Authored: Mahajan, SS, 2008-10-17 21:22:46 Dopamine loaded synaptic vesicles are docked, inside the synapse in the presynaptic cell, close to the plasmamembrane. The docking brings the vesicles in close proximity to the release site to fascilitate the release of dopamine. Some of the molecules involved in the docking process are Munc 18, Rab3a, Rab 3 interacting molecule (RIM). The priming reaction brings docked but unprimed synaptic vesicles into a releaseable pool. Priming involes formation of the trimeric SNARE complex between two plasmamembrane proteins SNAP25 and Syntaxin and vesicular membrane protein, VAMP2. Edited: Gillespie, ME, 2009-11-19 Pubmed15935055 Pubmed17989281 Pubmed18617632 Pubmed9701566 Reactome Database ID Release 43380574 Reactome, http://www.reactome.org ReactomeREACT_15517 Reviewed: Restituito, S, 2008-11-27 12:38:49