GAD2 Activity Complex Docked GABA loaded synaptic veiscle SNARE complex Release of GABA at the synapse Authored: Mahajan, SS, 2010-06-29 Edited: Mahajan, SS, 2010-08-03 GABA synaptic vesicles are fused to the presynaptic terminal membrane with the help of SNARE complex proteins, synaptobrevin located in the synaptic vesicle, SNAP 25 and syntaxin located in the plasma membrane. Complexin optimizes partially assembled SNARES for Ca2+ dependent exocytosis. Fusion of the synaptic vesicle is triggered by the influx of Ca2+ through N, P/Q Ca2+ channels, which binds to synaptobrevin on the synaptic vesicles triggering a series of steps leading to fusion of the synaptic vesicle to the presynatic terminal membrane and release of GABA. Pubmed11017172 Pubmed12750892 Pubmed19375301 Reactome Database ID Release 43888589 Reactome, http://www.reactome.org ReactomeREACT_23813 Reviewed: Restituito, S, 2008-11-27 12:38:49