Stalled Pol II complex with damaged DNA hybrid Active Pol II transcription complex with damaged DNA hybrid RNA Pol II is blocked by the lesion leading to reduced transcription At the site of damage, the Pol II complex is arrested resulting in reduced levels of transcription. Several models have been proposed to explain the mechanism of this transcriptional downregulation. These include a. hyperphosphorylation of Pol II resulting in aborted entry to new pre-initiation complexes b. sequestration of TATA-binding proteins (TBP) c. enhanced use of TFIIH complexes for repair purposes precluding their use in transcription.<BR> Authored: Gopinathrao, G, 2004-02-02 17:30:34 GENE ONTOLOGYGO:0000716 Reactome Database ID Release 43109972 Reactome, http://www.reactome.org ReactomeREACT_1947