ERCC1:XPF complex Transcription-coupled (TC) repair complex Stalled Pol II complex with damaged DNA hybrid TFIIH Assembly of repair proteins at the site of Pol II blockage A proper assembly of repair complex may require displacement of Pol II from the damage site exposing a significant length of the corresponding template DNA with the lesions. Speculations on the mode of this displacement of Pol II are available from experimental evidences: a. CSB mediated dissociation of Pol II b. degradation of Pol II c. CSB mediated remodeling of damaged DNA-RNA PII interface etc.<BR>The TC-repair complex now consists of damaged DNA template: nascent mRNA hybrid. The damage site needs to be exposed to subsequent endonuclease activities.<BR> Authored: Gopinathrao, G, 2004-01-29 18:08:32 Reactome Database ID Release 43109973 Reactome, http://www.reactome.org ReactomeREACT_1584