BRCA1:BRCA2:PALB2 Formation of the BRCA1-PALB2-BRCA2 complex Authored: Matthews, L, 2009-11-09 BRCA2 plays a critical role in the initiation of DNA repair by loading the repair protein RAD51 onto single-stranded DNA for homologous recombination (HR) (Reviewed in Lord and Ashworth, 2007). PALB2 associates with BRCA2 and also functions in the loading of the the BRCA2-RAD51 repair complex onto DNA (Xia et al., 2006 ). BRCA1, through its direct interaction with PALB2, may regulate recombinational repair partly by modulating the PALB2- dependent loading of the BRCA2-RAD51 repair machinery at the sites of DNA breaks (Sy et al., 2009). Edited: Matthews, L, 2010-02-26 Pubmed16793542 Pubmed17549079 Pubmed19369211 Reactome Database ID Release 43446345 Reactome, http://www.reactome.org ReactomeREACT_21405 Reviewed: Huang, TT, 2009-11-05