Phosphorylation of FANCI by ATM/ATR Authored: Matthews, L, 2009-05-02 17:26:55 EC Number: 2.7.11 Edited: Matthews, L, 2009-05-20 15:51:04 FANCI phosphorylation may function as a molecular switch to turn on the Fanconi anemia pathway in response to DNA damage or replication fork stress (Ishiai et al., 2008). Multiple phosphorylation sites within FANCI are functionally important for inducing monoubiquitination of FANCD2. Several lines of evidence support the notion that the ATR kinase is involved in this phosphorylation (Ishiai et al., 2008). Pubmed18931676 Reactome Database ID Release 43420769 Reactome, http://www.reactome.org ReactomeREACT_18335 Reviewed: Huang, TT, 2009-05-20 17:48:24