mono-ubiquitinated FANCI FA core complex ubiquitin Monoubiquitination of FANCI by the FA ubiquitin ligase complex Authored: Matthews, L, 2009-05-02 17:26:55 EC Number: 6.3.2.19 Edited: Matthews, L, 2009-05-20 15:51:04 FANCI is monoubiquitinated on lysine 523 in an FA core-complex-dependent manner (Sims et al., 2007; Smogorzewska et al. 2007). FANCD2 and FANCI are mutually dependent on each other for their respective monoubiquitination. However, multiple phosphorylation of FANCI but not monoubiquitination is crucial for FANCD2 activation following DNA damage (Ishiai et al., 2008). Pubmed17412408 Pubmed17460694 Pubmed18931676 Reactome Database ID Release 43419539 Reactome, http://www.reactome.org ReactomeREACT_18367 Reviewed: Huang, TT, 2009-05-20 17:48:24