CCT/TriC(ATP)-associated actin CCT/TriC(ADP) Hydrolysis of ATP and release of folded actin from CCT/TriC Authored: Matthews, L, 2008-12-01 04:46:41 Edited: Matthews, L, 2009-02-21 05:37:28 Pubmed12732144 Pubmed1351421 Reactome Database ID Release 43390453 Reactome, http://www.reactome.org ReactomeREACT_16915 Reviewed: Cowan, NJ, 2009-01-21 16:47:24 TriC/CCT-mediated beta-actin folding involves rapid ATP-independent formation of a binary complex, followed by a slower ATP-dependent release of the native product (Gao et al., 1992). Group II chaperonins enclose substrate proteins following substrate binding through the formation of a "built- in" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003). has a Stoichiometric coefficient of 8