EIF5A(Dhp) EIF5A EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine Authored: Johansson, HE, 2007-11-28 23:26:30 EC Number: 2.5.1.46 Edited: D'Eustachio, P, 2007-11-28 23:33:46 Pubmed16452303 Reactome Database ID Release 43204617 Reactome, http://www.reactome.org ReactomeREACT_12481 Reviewed: Jassal, B, 2008-01-28 15:51:00 The reaction of EIF5A, spermidine, and NAD+ to form EIF5A(Dhp), 1,3-diaminopropane, and NADH + H+ is reversible in vitro. Under physiological conditions, the reverse reaction is probably minimized by the rapid, irreversible conversion of FIF5A(Dhp) to EIF5A(Hyp).