SUMF1:SUMF2 SUMF2 inhibits SUMF1-mediated activation of arylsulfatases Authored: Jassal, B, 2011-09-28 Edited: Jassal, B, 2011-09-28 Pubmed15708861 Pubmed15962010 Reactome Database ID Release 431614336 Reactome, http://www.reactome.org ReactomeREACT_121184 Reviewed: D'Eustachio, P, 2012-05-14 Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005). SUMF2 can interact with sulfatases with and without SUMF1 (Zito et al. 2005).