acyl-GPI uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide Authored: D'Eustachio, P, 2005-04-04 21:01:34 Edited: D'Eustachio, P, 0000-00-00 00:00:00 In the endoplasmic reticulum, the precursor form of urokinase plasminogen activator receptor is transamidated at residue 305, replacing the 30 carboxyterminal residues of the protein with an acylated glucosylphosphatidylinositol (acyl-GPI) moiety. The released carboxyterminal propeptide has no known function. The reaction is catalyzed by GPI transamidase, a complex of at least five proteins associated with the lumenal surface of the endoplasmic reticulum membrane (Yu et al. 1997; Ohishi et al. 2001; Hong et al. 2003). Pubmed11483512 Pubmed12802054 Pubmed9356492 Reactome Database ID Release 43162836 Reactome, http://www.reactome.org ReactomeREACT_1777