PathwayStep5057 Binding of SHC1 by phosphorylated IGF1R Phosphorylation of SHC1 by IGF1R PathwayStep5922 PathwayStep5921 SHC-related events triggered by IGF1R Authored: May, B, 2012-08-06 Edited: May, B, 2012-08-06 Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). Phosphorylated SHC then binds GRB:SOS, which activates RAS-RAF-MAPK signaling. Pubmed17598937 Pubmed18927274 Pubmed20098959 Pubmed20975071 Pubmed22649417 Reactome Database ID Release 432428933 Reactome, http://www.reactome.org ReactomeREACT_150139 Reviewed: Holzenberger, Martin, 2012-11-09 SHC-mediated signalling