PathwayStep5101 IGF1/2:p-IGF1R binds IRS2 IGF1/2:p-IGF1R phosphorylates IRS1/2/4 IGF1/2:p-IGF1R binds IRS1/4 PathwayStep5924 PathwayStep5926 PathwayStep5925 IRS-related events triggered by IGF1R Authored: May, B, 2012-08-06 Edited: May, B, 2012-08-06 Pubmed17598937 Pubmed18927274 Pubmed20098959 Pubmed20975071 Pubmed21042815 Pubmed22649417 Reactome Database ID Release 432428928 Reactome, http://www.reactome.org ReactomeREACT_150203 Reviewed: Holzenberger, Martin, 2012-11-09 The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling. IRS-mediated signalling