PathwayStep1386 Expression of NPAS2 Expression of BMAL1 (ARNTL). Expression of CLOCK Expression of ELOVL3 PathwayStep5959 PathwayStep5940 PathwayStep5941 Circadian Repression of Expression by REV-ERBA Authored: May, B, 2011-06-22 Edited: May, B, 2011-06-22 Pubmed18037887 Pubmed20581824 REV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thus REV-ERBA and RORA appear to compete to repress or activate genes, repectively. Reactome Database ID Release 431368071 Reactome, http://www.reactome.org ReactomeREACT_118789 Reviewed: Delaunay, F, 2012-01-28