Phosphorylation of beta-catenin at Ser45 by CK1 alpha Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 PathwayStep5837 PathwayStep5835 PathwayStep5836 PathwayStep5834 Beta-catenin phosphorylation cascade Authored: Kimelman, D, 2007-04-03 12:34:14 Degradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated phosphorylation at Thr41, Ser37 and Ser33 (Amit et al., 2002 ; Lui et al., 2002). Edited: Matthews, L, 2007-04-19 08:07:52 Pubmed11955436 Pubmed12000790 Reactome Database ID Release 43196299 Reactome, http://www.reactome.org ReactomeREACT_11065 Reviewed: Pagano, M, 2007-04-27 13:02:18