Association of beta-catenin with the destruction complex Assembly of the destruction complex Degradation of ubiquitinated -beta catenin by the proteasome Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex Phosphorylation of APC component of the destruction complex Multi-ubiquitination of phospho-beta-catenin by SCF-beta-TrCP1 Association of beta-catenin with the SCF-beta-TrCP1 ubiquitin ligase complex PathwayStep5841 PathwayStep5840 PathwayStep5839 PathwayStep5838 PathwayStep5833 PathwayStep5832 PathwayStep5842 PathwayStep5843 Beta-catenin phosphorylation cascade Degradation of beta-catenin by the destruction complex Authored: Kimelman, D, 2007-04-03 12:34:14 Edited: Matthews, L, 2007-04-03 12:38:03 Pubmed17143292 Reactome Database ID Release 43195253 Reactome, http://www.reactome.org ReactomeREACT_11063 Reviewed: Pagano, M, 2007-04-27 13:02:18 The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).