PathwayStep800 PathwayStep557 PathwayStep656 PathwayStep768 PathwayStep758 PathwayStep757 PathwayStep753 PathwayStep755 PathwayStep788 Integrin alpha2beta1 collagen adhesion Integrin alphaIIb beta3 signaling VLA-4 binds JAM-B MAC1 binds JAM-C LFA1 binds JAM-A Integrin alphaXbeta2 binds JAM-C Integrin alpha 5 beta 1 binds fibronectin Basigin binds to integrins Interaction of integrin alphaVbeta3 with PECAM-1 MADCAM interacts with Integrin alpha4beta7 Interaction of integrin alpha5beta1 with Osteopontin Interaction of integrin alpha3beta1 with Thrombospondin-1 Interaction of integrin alpha3beta1 with Laminin-5 Interaction of integrin alpha2beta1 with Lamini-5 Interaction of integrin alpha1beta1 with Laminin-1 VCAM-1interacts with VLA-4 Interaction of integrin alpha4beta1 with Osteopontin Interaction of integrin alpha4beta1 with Thrombospondin-1 Interaction of integrin alpha4beta1 with Fibronectin Interaction of integrin alpha9beta1 with tenascin Interaction of integrin alpha6beta1 with Laminin-1 Interaction of integrin alpha7beta1 with Laminin-1 Interaction of integrin alpha6beta4 with Laminin-5 Interaction of integrin alpha8beta1 with Fibronectin Interaction of integrin alpha7beta1 with Laminin-2 Interaction of integrin alpha8beta1 with Tenascin-c Interaction of integrin alpha8beta1 with Osteopontin Interaction of integrin alpha9beta1 with VCAM-1 Interaction of integrin alpha9beta1 with Osteopontin Interaction of integrin alpha1beta1 with Type IV collagen ICAMs 1-4 bind to Integrin LFA-1 Interaction of integrin alphaVbeta3 with Bone sialoprotein 2 Interaction of integrin alphaVbeta8 with vitronectin Interaction of integrin alphaXbeta2 with fibrin Interaction of integrin alphaVbeta5 with vitronectin Interaction of integrin alphaVbeta6 with Fibronectin Interaction of integrin alphaDbeta2 with fibrin Interaction of integrin alphaVbeta1 with Fibronectin Interaction of integrin alpha10beta1 with Collagen-II Interaction of integrin alpha11beta1 with Collagen-I Adhesion of integrin alphaIIbbeta3 to fibrin network Interaction of integrin alphaIIbbeta3 with von Willebrand factor Interaction of integrin alphaIIb beta 3 with Thrombospondin Interaction of integrin alphaVbeta3 with Fibrillin Interaction of integrin alphaVbeta3 with von Willbrand Factor Interaction of integrin alphaEbeta7 with Cadherin-1 Interaction of integrin alphaIIbbeta3 with Fibronectin Interaction of integrin alphaVbeta3 with vitronectin Interaction of integrin alphaVbeta3 with Fibronectin Interaction of integrin alphaVbeta3 with Tenascin PathwayStep5900 PathwayStep5903 PathwayStep5904 PathwayStep5901 PathwayStep5902 PathwayStep5907 PathwayStep5908 PathwayStep5905 PathwayStep5906 PathwayStep5909 PathwayStep5917 PathwayStep5916 PathwayStep5915 PathwayStep5914 PathwayStep5913 PathwayStep5912 PathwayStep5911 PathwayStep5910 PathwayStep5891 PathwayStep5892 PathwayStep5890 PathwayStep5895 PathwayStep5896 PathwayStep5893 PathwayStep5894 PathwayStep5889 PathwayStep5888 PathwayStep5887 PathwayStep5886 PathwayStep5880 PathwayStep5881 PathwayStep5882 PathwayStep5883 PathwayStep5884 PathwayStep5885 PathwayStep5878 PathwayStep5877 PathwayStep5879 PathwayStep5898 PathwayStep5897 PathwayStep5899 Integrin cell surface interactions Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Edited: Garapati, P V, 2008-03-11 10:20:45 Pubmed12231361 Pubmed15147720 Pubmed8866399 Reactome Database ID Release 43216083 Reactome, http://www.reactome.org ReactomeREACT_13552 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 The extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength and also influences the behavior and differentiation state of cells in contact with it. The ECM are diverse in composition, but they generally comprise a mixture of fibrillar proteins, polysaccharides synthesized, secreted and organized by neighboring cells. Collagens, fibronectin, and laminins are the principal components involved in cell matrix interactions; other components, such as vitronectin, thrombospondin, and osteopontin, although less abundant, are also important adhesive molecules.<br>Integrins are the receptors that mediate cell adhesion to ECM. Integrins consists of one alpha and one beta subunit forming a noncovalently bound heterodimer. 18 alpha and 8 beta subunits have been identified in humans that combine to form 24 different receptors. <br>The integrin dimers can be broadly divided into three families consisting of the beta1, beta2/beta7, and beta3/alphaV integrins. beta1 associates with 12 alpha-subunits and can be further divided into RGD-, collagen-, or laminin binding and the related alpha4/alpha9 integrins that recognise both matrix and vascular ligands. beta2/beta7 integrins are restricted to leukocytes and mediate cell-cell rather than cell-matrix interactions, although some recognize fibrinogen. The beta3/alphaV family members are all RGD receptors and comprise aIIbb3, an important receptor on platelets, and the remaining b-subunits, which all associate with alphaV. It is the collagen receptors and leukocyte-specific integrins that contain alpha A-domains.