PathwayStep5927 PathwayStep5923 SHC-related events triggered by IGF1R IRS-related events triggered by IGF1R IGF1R signaling cascade After autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activity (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, and Siddle et al. 2012). IRS1/2/4 can bind both PI3K (via the p85 subunit of PI3K) and the GRB2:SOS complex. PI3K activates PKB (AKT, AKT1) signaling. GRB:SOS stimulates RAS to exchange GDP for GTP leading to activation of RAF and MAPK. Authored: May, B, 2012-08-06 Edited: May, B, 2012-08-06 Pubmed17598937 Pubmed18927274 Pubmed20098959 Pubmed20975071 Pubmed21042815 Pubmed22649417 Reactome Database ID Release 432428924 Reactome, http://www.reactome.org ReactomeREACT_150210 Reviewed: Holzenberger, Martin, 2012-11-09