IGF1/2 binds IGF1R Autophosphorylation of IGF1R PathwayStep5919 PathwayStep5928 PathwayStep5920 IGF1R signaling cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Authored: May, B, 2012-07-07 Binding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS-RAS-RAF-MAPK (ERK) pathway and the PI3K-PKB (AKT) pathway (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parella et al. 2010, Annunziata et al. 2011, Siddle et al. 2012, Holzenberger 2012). Edited: May, B, 2012-07-07 Pubmed17598937 Pubmed18927274 Pubmed20098959 Pubmed20975071 Pubmed21042815 Pubmed22044904 Pubmed22649417 Reactome Database ID Release 432404192 Reactome, http://www.reactome.org ReactomeREACT_150359 Reviewed: Holzenberger, Martin, 2012-11-09