PathwayStep626 PIP3 recruits PDK1 and AKT to the membrane Gbeta:gamma recruits PI3K gamma G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 PathwayStep5235 PIP3 binds to RhoA and activates it PathwayStep5779 PathwayStep5778 G beta:gamma signalling through PI3Kgamma Authored: Jupe, S, 2009-03-04 10:18:49 Edited: Jupe, S, 2009-09-09 PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3. Pubmed17041586 Pubmed17916723 Reactome Database ID Release 43392451 Reactome, http://www.reactome.org ReactomeREACT_19290 Reviewed: Akkerman, JW, 2009-06-03