PathwayStep1879 Hydrolysis of phosphatidylcholine Phosphorylation of cPLA2 by ERK-2 Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase PathwayStep5802 PathwayStep5801 phospho-PLA2 pathway Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Phospholipase A2 (PLA2) enzymes hydrolyze arachidonic acid (AA) from the sn-2 position of phospholipids. AA is a precursor of eicosanoids, lipid mediators involved in inflammtory responses. PLA2 enzymes function as regulators of phospholipid acyl turnover, either as housekeepers for membrane repair or for the production of imflammatory lipid mediators. There are diverse forms of PLA2 enyzmes including secretory (sPLA2), calcium-independent and cytosolic (cPLA2). The cPLA2 form which mediates arachidonic acid release is annotated here. Pubmed9201969 Reactome Database ID Release 43111995 Reactome, http://www.reactome.org ReactomeREACT_15466 Reviewed: Castagnoli, L, 2008-11-06 12:55:54