IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel Release of calcium from intracellular stores by IP3 receptor activation PathwayStep2071 PathwayStep2072 Activation of PLC beta-1/4 PIP2 hydrolysis Inactivation of PLC beta PathwayStep5804 PathwayStep5800 PathwayStep5798 PathwayStep5799 Ca-dependent events PLC beta mediated events Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed1335363 Pubmed16183910 Pubmed9218123 Reactome Database ID Release 43112043 Reactome, http://www.reactome.org ReactomeREACT_15426 Reviewed: Castagnoli, L, 2008-11-06 12:55:54 The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.