PathwayStep5783 PathwayStep5780 G beta:gamma signalling through PLC beta G beta:gamma signalling through PI3Kgamma G-protein beta:gamma signalling Authored: Jupe, S, 2009-03-13 10:42:02 Edited: Jupe, S, 2009-09-09 Pubmed18834311 Reactome Database ID Release 43397795 Reactome, http://www.reactome.org ReactomeREACT_19388 Reviewed: Akkerman, JW, 2009-06-03 The classical role of the G-protein beta/gamma dimer was believed to be the inactivation of the alpha subunit, Gbeta/gamma was viewed as a negative regulator of Galpha signalling. It is now known that Gbeta/gamma subunits can directly modulate many effectors, including some also regulated by G alpha.