Metabotropic glutamate receptors bind glutamate GPRC6A can bind L-alpha amino acids and calcium Calcium-sensing receptor binds calcium T1R1/T1R3 dimer is the umami taste receptor T1R2/T1R3 dimer is a sweet taste receptor PathwayStep3368 PathwayStep5725 PathwayStep5726 PathwayStep5727 PathwayStep5723 PathwayStep5724 Class C/3 (Metabotropic glutamate/pheromone receptors) Authored: Jassal, B, 2009-05-12 14:18:01 Edited: Jassal, B, 2009-05-12 14:18:01 Pubmed12782243 Pubmed17266540 Reactome Database ID Release 43420499 Reactome, http://www.reactome.org ReactomeREACT_18319 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 The class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Bräuner-Osborne H et al, 2007). Family C GPCRs have a large extracellular N-terminus which binds the orthosteric (endogenous) ligand. The shape of this domain is often likened to a clam. Several allosteric ligands to these receptors have been identified and these bind within the seven transmembrane region. GABAB heterodimeric receptor binds GABA