G alpha (s) activates adenylate cyclase PathwayStep2077 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs Liganded Gs-activating GPCR acts as a GEF for Gs cAMP degradation by Phosphodiesterases Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate The Ligand:GPCR:Gs complex dissociates Inactive G alpha (s) reassociates with G beta:gamma G alpha (s) auto-inactivates by hydrolysing GTP to GDP PathwayStep5731 PathwayStep5730 PathwayStep5734 PathwayStep5735 PathwayStep5732 PathwayStep5733 PathwayStep5736 G alpha (s) signalling events Authored: Jupe, S, 2009-04-23 16:22:25 Edited: Jupe, S, 2009-09-09 Pubmed12036966 Reactome Database ID Release 43418555 Reactome, http://www.reactome.org ReactomeREACT_19327 Reviewed: Akkerman, JW, 2009-06-03 The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.