Collagen type VII binds laminin-322 and collagen IV Formation of anchoring fibrils Cleavage of collagen VII NC2 region by BMP1 Collagen type VII dimerization PathwayStep5993 PathwayStep5995 PathwayStep5994 PathwayStep5996 Anchoring fibril formation Authored: Jupe, S, 2012-04-30 Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009, Has & Kern 2010). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptide is then removed by Bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Villone et al. 2008, Gordon & Hahn 2010). Edited: Jupe, S, 2012-11-12 Pubmed11986329 Pubmed18599485 Pubmed19116634 Pubmed19693541 Pubmed19945617 Pubmed19945621 Reactome Database ID Release 432214320 Reactome, http://www.reactome.org ReactomeREACT_150268 Reviewed: Kalamajski, Sebastian, 2012-10-08 Reviewed: Raleigh, Stewart, 2012-10-08 Reviewed: Ricard-Blum, Sylvie, 2012-11-19