PathwayStep6215 PathwayStep6214 PathwayStep6216 PathwayStep6217 Inactivation of Cdc42 and Rac Authored: Garapati, P V, 2008-09-05 06:02:05 Edited: Garapati, P V, 2008-09-05 06:02:05 Reactome Database ID Release 43428543 Reactome, http://www.reactome.org ReactomeREACT_19342 Reviewed: Kidd, T, 2009-08-18 Rho family GTPases including Rac, Rho, and Cdc42 are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed an important role for Cdc42 and Rac in Robo repulsion. Robo controls the activity of Rho GTPases by interacting with a family of Slit/Robo specific GAPs (SrGAPs) and Vilse/CrossGAP. SrGAPs inactivate Cdc42 and Vilse/CrossGAP specifically inactivates Rac1. SrGAP binds Robo1:Slit2 Inactivation of Cdc42 KIAA1688/Vilse binds Robo1:Slit2 Inactivation of Rac1