PathwayStep6185 PathwayStep6188 PathwayStep6187 PathwayStep6186 Netrin mediated repulsion signals Authored: Garapati, P V, 2008-07-16 14:42:16 Edited: Garapati, P V, 2008-07-30 10:24:23 Reactome Database ID Release 43418886 Reactome, http://www.reactome.org ReactomeREACT_22384 Reviewed: Cooper, HM, 2010-02-16 Unc5 netrin receptors mediate repellent responses to netrin. Four Unc5 members have been found in humans: Unc5A, B, C and D. Different studies have suggested that long-range repulsion to netrin requires the cooperation of Unc5 and DCC, but that Unc5 without DCC is sufficient for short-range repulsion. The binding of netrin to Unc5 triggers the phosphorylation of Unc5 in its ZU-5 domain. Several proteins have been proposed to interact with Unc5 family members in mediating a repellent response, including tyrosine phosphatase Shp2, the F-actin anti-capping protein Mena, and ankyrin. UNC-5 binds Netrin-1 Shp2 binds pUnc5C Phosphorylation of Unc5C DCC heterodimerizes with UNC-5:Netrin-1