PathwayStep6181 PathwayStep6180 PathwayStep6183 PathwayStep6182 PathwayStep6172 PathwayStep6174 PathwayStep6173 PathwayStep6176 PathwayStep6175 PathwayStep6178 PathwayStep6177 PathwayStep6179 DCC mediated attractive signaling Authored: Garapati, P V, 2008-07-16 14:42:16 Edited: Garapati, P V, 2008-07-30 10:24:23 Pubmed11239160 Pubmed11817894 Pubmed12149262 Pubmed15494733 Pubmed15557120 Pubmed15960985 Pubmed17254765 Pubmed9950216 Reactome Database ID Release 43418885 Reactome, http://www.reactome.org ReactomeREACT_22351 Reviewed: Cooper, HM, 2010-02-16 The DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosine kinase 2/FAK and src family kinases bind constitutively to the cytoplasmic domain of DCC and their activation couples to downstream intracellular signaling complex that directs the organization of actin. DCC interacting NCK-1 RhoGTPase GEF's recruited to DCC Recruitment of Src and Fyn to DCC:FADK1 Phosphorylation of DCC by Fyn FADK1 interaction with DCC Phosphorylation of FADK1 DCC interaction with Netrin-1 Netrin-1 induced DCC clustering Recruitment of ABLIM to the plasma membrane Recruitment and activation of N-WASP by Cdc42 Activation of Rac1 Activation of Cdc42