PathwayStep6194 PathwayStep6193 PathwayStep6196 PathwayStep6195 PathwayStep6190 PathwayStep6192 PathwayStep6191 PathwayStep6198 PathwayStep6197 PathwayStep6199 PathwayStep6184 PathwayStep6189 PathwayStep6205 PathwayStep6200 Role of second messengers in netrin-1 signaling Netrin mediated repulsion signals DCC mediated attractive signaling Netrin-1 signaling Authored: Garapati, P V, 2008-07-16 14:42:16 Edited: Garapati, P V, 2008-07-30 10:24:23 Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion. Pubmed10499167 Pubmed18269208 Reactome Database ID Release 43373752 Reactome, http://www.reactome.org ReactomeREACT_22237 Reviewed: Cooper, HM, 2010-02-16 DCC interaction with ROBO-1 DCC interaction with SIAH1 DCC interaction with Ezrin Phosphorylation and activation of Ezrin Neogenin binds Netrin-1 Netrin-4 binds DCC/UNC5A Myosin-X binds DCC/Neogenin Neogenin binds repulsive guidance molecules (RGDs) PIKE-L interaction with UNC5B DCC interaction with SIAH2 Translocation of Ezrin to plasma membrane