PathwayStep6276 PathwayStep6277 PathwayStep6274 PathwayStep6275 PathwayStep6278 PathwayStep6279 PathwayStep6280 Neurofascin interacts with syntenin-1 Doublecortin binds phosphorylated neurofascin Neurofascin binds contactin-1:CASPR complex Trans-homodimerization of Neurofascin Neurofascin binds Ankyrin-G Phosphorylation of Neurofascin Neurofascin and NrCAM heterodimerization Neurofascin interactions Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 Neurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms identified in Neurofascin of which two of them are well studied the 186kDa commonly referred to as neuronal form and is present in node of Ranvier neurons and the 155kDa form known as a glial form present in schwann cells.<br>Neurofascin colocalizes with NrCAM and ankyrinG at the nodes of Ranvier. Neurofascin participates in transheterophilic adhesion with NrCAM and stimulates neurite outgrowth in chicken tectal neurons. The last few amino acids of neurofascin form the PDZ class I binding motif (SLA) and through these last few amino acids it associates with syntenin-1. Pubmed10662501 Pubmed19356150 Reactome Database ID Release 43447043 Reactome, http://www.reactome.org ReactomeREACT_22312 Reviewed: Maness, PF, 2010-02-16