PathwayStep6282 PathwayStep6283 PathwayStep6284 PathwayStep6285 NrCAM binds axonin-1 NrCAM binds Ankyrin-G NrCAM binds synapse-associated proteins NrCAM binds Neuropilin-2 NrCAM interactions Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 Pubmed10662501 Pubmed16202709 Pubmed19356150 Reactome Database ID Release 43447038 Reactome, http://www.reactome.org ReactomeREACT_22329 Reviewed: Maness, PF, 2010-02-16 The NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to bind to ankyrins. The last C-terminal amino acids of NrCAM form a PDZ-binding motif and can interact with SAP (synapse-associated protein) 102 and SAP97. Member of the GPI-anchored TAG-1/axonin-1 have been shown to interact with NrCAM. NrCAM also binds the Sema3B receptor NP-2 to mediate repulsive axon guidance.