PathwayStep6246 PathwayStep6245 PathwayStep6248 PathwayStep6247 Interaction between L1 and Ankyrins Ankyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by three genes (ankyrin-G, -B and -R) of which ankyrin-G and -B are the major forms expressed in the developing nervous system. Ankyrins bind to the cytoplasmic domain of L1 CAMs and couple them and ion channel proteins, to the spectrin cytoskeleton. This binding enhances the homophilic adhesive activity of L1 and reduces its mobility within the plasma membrane. L1 interaction with ankyrin mediates branching and synaptogenesis of cortical inhibitory neurons.<br> Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 Pubmed16904324 Pubmed18839070 Pubmed19356150 Pubmed20156840 Reactome Database ID Release 43445095 Reactome, http://www.reactome.org ReactomeREACT_22266 Reviewed: Maness, PF, 2010-02-16 L1 linked to actin cytoskeleton by ankyrin Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 Phosphorylation of Y1229 in L1 L1 dimer binds Ankyrin