PathwayStep6224 PathwayStep6226 PathwayStep6225 PathwayStep6227 Role of Abl in Robo-Slit signaling Abl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed back on the receptor (by down regulating through phosphorylation) to adjust the sensitivity of the pathway.<br>Abl cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that Abl simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance. Authored: Garapati, P V, 2008-09-05 06:02:05 Edited: Garapati, P V, 2008-09-05 06:02:05 Pubmed12441051 Pubmed15207230 Pubmed15207236 Reactome Database ID Release 43428890 Reactome, http://www.reactome.org ReactomeREACT_19230 Reviewed: Kidd, T, 2009-08-18 Recruitment of CAP to Abl Activation of CLASP Phosphorylation of Rob1 by Abl kinase Interaction of Abl with Robo1:Slit2