PathwayStep6219 PathwayStep6220 PathwayStep6222 PathwayStep6221 Activation of Rac A low level of Rac activity is essential to maintain axon outgrowth and Robo activation recruits Sos, a dual specificity GEF to the plasma membrane via Dock to activate Rac during midline repulsion. Authored: Garapati, P V, 2008-09-05 06:02:05 Edited: Garapati, P V, 2008-09-05 06:02:05 Reactome Database ID Release 43428540 Reactome, http://www.reactome.org ReactomeREACT_19226 Reviewed: Kidd, T, 2009-08-18 Recruitment of Sos to plasma membrane Recruitment of PAK to Nck Activation of Rac by Sos Nck binds Robo1:Slit2