PathwayStep6106 PathwayStep6107 PathwayStep6103 PathwayStep6102 PathwayStep6105 PathwayStep6104 Active Rac1 interacts with Plexin-B1:Sema4D Rnd1 interacts with Plexin-B1:Sema4D SEMA4D interacts with Plexin-B1:Met Inactivation of Rho-GTP by p190RhoGAP p190RhoGAP binds Plexin-B1 Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity Sema4D mediated inhibition of cell attachment and migration Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:38 Pubmed14770294 Pubmed16314868 Pubmed18374575 Reactome Database ID Release 43416550 Reactome, http://www.reactome.org ReactomeREACT_19266 Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho. Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01