PathwayStep6118 PathwayStep6119 PathwayStep6121 PathwayStep6120 PathwayStep6123 PathwayStep6122 PathwayStep6125 PathwayStep6124 Inactivation of R-Ras by Sema3A-Plexin-A GAP activity Inhibition of integrin activation by sequestering PIP5KIgamma Recruitment of Rnd1 to Plexin A Plexin-A binds to neuropilin-1 Phosphorylation of Plexin-A Sema3A binds Nrp-1 bound to PlexinA Rac1 binds PlexinA Activation of Rac1 by FARP2 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:38 Pubmed16286926 Pubmed16930978 Pubmed18374575 Pubmed18580951 Reactome Database ID Release 43399955 Reactome, http://www.reactome.org ReactomeREACT_19279 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01 Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity.