PathwayStep6109 PathwayStep6112 PathwayStep6111 PathwayStep6110 PathwayStep6113 ROCK activation by Rho SEMA4D interacts with Plexin-B1:ErbB2 LARG and PDZ-RhoGEF binds to Plexin-B1 LIM kinase phosphorylation by ROCK Activation of Rho by LARG and PDZ-RhoGEF Myosin regulatory light chain phosphorylation by ROCK PathwayStep5772 Sema4D induced cell migration and growth-cone collapse Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:38 Pubmed12220504 Pubmed15210733 Pubmed15818466 Pubmed18374575 Reactome Database ID Release 43416572 Reactome, http://www.reactome.org ReactomeREACT_19277 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01 Sema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates MLC to induce actomyosin stress fiber contraction and to direct the assembly of focal adhesion complexes and integrin-mediated adhesion.