PathwayStep6137 PathwayStep6138 PathwayStep6135 PathwayStep6136 PathwayStep6134 Activation of Fyn CRMPs in Sema3A signaling Authored: Garapati, P V, 2009-03-23 09:59:28 CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse. Edited: Garapati, P V, 2009-03-23 10:00:38 Pubmed17607942 Reactome Database ID Release 43399956 Reactome, http://www.reactome.org ReactomeREACT_19199 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01 Recruitment and activation of Cdk5 Phosphorylation of CRMPs by Cdk5 Phosphorylation of CRMPs by GSK3beta Tyrosine phosphorylation of CRMPs by Fes