PathwayStep6129 PathwayStep6128 PathwayStep6131 PathwayStep6132 PathwayStep6130 PathwayStep6127 Phosphorylation of LIMK-1 by PAK Dimerization of LIMK1 by Hsp90 Activation of PAK by Rac1 Autophosphorylation of PAK Phosphorylation of cofilin by LIMK-1 Transphosphorylation of pLIMK1 Sema3A PAK dependent Axon repulsion Activated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin. Authored: Garapati, P V, 2009-03-23 09:59:28 Edited: Garapati, P V, 2009-03-23 10:00:38 Pubmed11276226 Pubmed11604131 Pubmed12593985 Pubmed18374575 Reactome Database ID Release 43399954 Reactome, http://www.reactome.org ReactomeREACT_19236 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01