PathwayStep6091 PathwayStep6090 PathwayStep6093 PathwayStep6092 PathwayStep6095 PathwayStep6094 PathwayStep6097 PathwayStep6096 PathwayStep6099 PathwayStep6098 Fibrillin-1 binds latent TGF-beta Elastic fibres bind associated proteins FBLN1, FBLN2 bind fibronectin Fibulin binds elastic fibres LTBP1, LTBP3 bind TGF-Beta Emilin is found in elastic fibres Latent TGF-beta-1 binds integrins LTBP4 binds TGF-Beta-1 Fibrillins bind BMPs Latent TGF-beta-3 binds integrins Molecules associated with elastic fibres Authored: Jupe, S, 2012-04-30 Edited: Jupe, S, 2012-11-12 Proteins found associated with microfibrils include vitronectin (Dahlback et al. 1990), latent transforming growth factor beta-binding proteins (Kielty et al. 2002, Munger & Sheppard 2011), emilin (Bressan et al. 1993, Mongiat et al. 2000), members of the microfibrillar-associated proteins (MFAPs, Gibson et al.1996), and fibulins (Roark et al. 1995, Yanagisawa et al. 2002). The significance of these interactions is not well understood. Proteoglycans such as versican (Isogai et al. 2002), biglycan, and decorin (Reinboth et al. 2002) can interact with the microfibrils. They confer specific properties including hydration, impact absorption, molecular sieving, regulation of cellular activities, mediation of growth factor association, and release and transport within the extracellular matrix (Buczek-Thomas et al. 2002). In addition, glycosaminoglycans have been shown to interact with tropoelastin through its lysine side chains (Wu et al. 1999) regulating tropoelastin assembly (Tu and Weiss, 2008). Pubmed10419484 Pubmed10821830 Pubmed11723132 Pubmed11805834 Pubmed12082143 Pubmed12124775 Pubmed12429738 Pubmed1689758 Pubmed18228265 Pubmed18547105 Pubmed21900405 Pubmed7534784 Pubmed8458869 Pubmed8557636 Reactome Database ID Release 432129379 Reactome, http://www.reactome.org ReactomeREACT_150331 Reviewed: Muiznieks, Lisa, 2012-11-02