PathwayStep6423 PathwayStep6424 PathwayStep6422 PathwayStep6425 Closure of gap junction c-src associates with Cx43 in gap junctions Association of Cx43 with ZO-1 Phosphorylation of Cx43 by c-src c-src mediated regulation of Cx43 function and closure of gap junctions Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09 Edited: Matthews, L, 2007-04-17 10:03:12 Pubmed10085299 Pubmed11124251 Pubmed12807735 Pubmed14638725 Pubmed15492000 Reactome Database ID Release 43191647 Reactome, http://www.reactome.org ReactomeREACT_11043 The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating (Zhou et al. 1999).