RNA Pol II (hypophosphorylated):capped pre-mRNA complex RNA Pol II (hypophosphorylated) complex bound to DSIF protein DSIF complex DSIF complex binds to RNA Pol II (hypophosphorylated) Authored: Matthews, L, Rice, AP, 2005-07-27 00:00:00 Edited: Matthews, L, 2005-07-26 23:29:22 Pubmed10757782 Pubmed12653964 Pubmed9450929 Pubmed9857195 Reactome Database ID Release 43167083 Reactome, http://www.reactome.org ReactomeREACT_6250 This HIV-1 event was inferred from the corresponding human RNA Pol II transcription event. DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160) (Wada et al. 1998). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding. Spt5 subunit of DSIF can be phosphorylated by P-TEFb (Ivanov et al. 2000).