PathwayStep6416 PathwayStep6415 Dab2 is recruited to the junctional plaques Dynamin is recruited to the gap junction plaque Formation of annular gap junctions Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09 Gap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate with gap junction plaques permitting the internalisation of plaques after clathrin association (Piehl et al., 2007). Pubmed11171382 Pubmed15194225 Pubmed15492000 Pubmed16195341 Pubmed17108328 Reactome Database ID Release 43196025 Reactome, http://www.reactome.org ReactomeREACT_11049 Until now, two kinds of annular gap junctions have been described. The first is a small vesicle like structure which permits gap junction plaque renewal without arrest of functionality [Jordan et al., 2001]. The second is a large annular structure, composed primarily of the junctional plaques of two adjacent cells (Jordan et al., 2001; Segretain et al., 2004).