Lysosomal degradation of gap junction plaques PathwayStep6419 PathwayStep6418 PathwayStep6417 Internalization of gap junction plaques Formation of annular gap junctions Gap junction degradation Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09 Edited: Matthews, L, 2007-03-27 16:29:06 Pubmed17108328 Pubmed7287816 Pubmed8522583 Reactome Database ID Release 43190873 Reactome, http://www.reactome.org ReactomeREACT_11035 The half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the lysosome. Degradation appears to involve the phosphorylation of Connexins as well as their interactions with other proteins (Piehl et al., 2007).